Postdoctoral position on high-resolution functional MRI and transcranial focused ultrasound at NeuroSpin, France

A postdoctoral position with Qi Zhu (https://scholar.google.com/citations?hl=en&user=cvBXeIYAAAAJ) is available in the Cognitive Neuroimaging Unit (www.unicog.org) at NeuroSpin. The position will be funded with a grant from the ANR, the French National Research Agency.

The postdoctoral fellow will work on a project with transversal collaboration among ultra-high field MRI, therapeutic ultrasound, and non-human primate (NHP) imaging experts (Benoit Larrat, Alexis Amadon, Nicolas Boulant, Wim Vanduffel). The aim is to use a combination of ultra-high-resolution fMRI (at 3T, 7T, and potentially 11.7T) and focused ultrasound to study the effect of therapeutic ultrasound on primate social behaviour and the neural mechanism behind it. The ultimate goal is to pave the way for improved treatments for social dysfunction.
Candidate profile
Candidates should have a PhD in a relevant field (e.g., Cognitive/Systems Neuroscience, Psychology, Biomedical physics), and ideally prior end-to-end experience with the use of fMRI and non-human primates, good programming, experimental and statistical skills. Prior experience with therapeutic ultrasound and more precisely brain applications of it would be a plus. A good level of English is required. Knowledge of the French language is an asset but not essential.

About NeuroSpin
NeuroSpin is a top-notch brain imaging center — a building entirely dedicated to the understanding of the brain, and the development of neuroscience and neuroimaging technologies. Three research labs currently share their expertise on site and provide a stimulating research environment. The facility is also open to additional external teams. NeuroSpin hosts 8 state-of-the-art neuroimaging systems including three human MRIs (3T, 7T, and soon a world-record 11.7 Tesla), three animal MRIs (7T, 11.7T, and 17.2T), a MEG system, several EEG and a 3-photon imaging system. In addition, mechanical and electronic workshops and staff are ready to support projects as well as a preclinical housing facility with all required equipment.

Practical information
The contract is for 2 years full time. The employment is with the CEA, the French Alternative Energies and Atomic Energy Commission. Interested candidates should send a curriculum vitae, a motivation letter, and two letters of recommendation (or the appropriate contact information) to Qi Zhu (qi.zhu@cea.fr). Evaluation of candidates will begin immediately and continue until the position is filled.

References
Zhu, Q., & Vanduffel, W. (2019). Submillimeter fMRI reveals a layout of dorsal visual cortex in macaques, remarkably similar to New World monkeys. Proceedings of the National Academy of Sciences of the United States of America, 116(6), 2306–2311. http://doi.org/10.1073/pnas.1805561116

Vancraeyenest, P., Arsenault, J. T., Li, X., Zhu, Q., Kobayashi, K., Isa, K., et al. (2020). Selective Mesoaccumbal Pathway Inactivation Affects Motivation but Not Reinforcement-Based Learning in Macaques. Neuron, 108(3), 568–581.e6. http://doi.org/10.1016/j.neuron.2020.07.013

Kamimura, H. A. S., Flament, J., Valette, J., Cafarelli, A., Badin, R. A., Hantraye, P., & Larrat, B. (2019). Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance. Journal of Cerebral Blood Flow and Metabolism, 39(7), 1191–1203. http://doi.org/10.1177/0271678X17753514

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NEUROSPIN is looking for a post-doctoral researcher on the MNE analysis of MEG-OPM

A post-doctoral position is available at the Cognitive NeuroImaging Unit (www.unicog.org) located at NeuroSpin, France’s advanced brain imaging center.

You will join a collaborative project between Neurospin and CEA Leti, focused on comparing two MEG technologies: Squid based MEG (MEGIN) and OPM MEG.

Optically pumped magnetometers are ultra-sensitive magnetic field detectors, which can operate at body temperature, and so can be brought closer to the head than the cryogenically-cooled field detectors that are currently used in MEG imaging. A few years ago CEA Leti have developed optically pumped magnetometers (OPM) based on helium-4 metastable atoms. They are now testing a prototype of MEG based on OPM array.  We are designing studies together to optimally exploit those sensors in combination with the cognitive designs and analysis pipelines available at NeuroSpin.

 Eligible qualifications for this position include:

  • Ph.D. in Physics, Engineering, Cognitive neuroscience, or related discipline
  • Thorough knowledge of the technical, theoretical and practical principles of M/EEG, and expertise in signal processing.
  • Fluent knowledge in computer programming (languages: Python, Matlab)
  • Knowledge of cognitive neuroscience

Knowledge of the French language is not required, but would be a bonus.

The position is funded for one year, with a start date around November 1, 2021. The postdoc will be based in the laboratory of Prof. Stanislas Dehaene at NeuroSpin. She/he will work on the pre-registered experiments, MEG/MEG-OPM data acquisition and adapted pipeline analyses already available, in coordination with the MEG team.

To apply, submit a CV, contact information for 2-3 references, and a cover letter highlighting relevant research experiences and interests directly to giovanna.santoro@cea.fr with “MNE analysis of MEG-OPM in the headline. Please apply before July 18, 2021.

NeuroSpin is France’s advanced brain-imaging center – a building entirely dedicated to the understanding of the human brain and the development of neuroscience technologies. Five laboratories currently share their expertise on site and provide a stimulating research environment. NeuroSpin hosts 8 state-of-the-art neuroimaging systems including three human MRIs (3T, 7T, and soon a world-record 11.7 Tesla), three animal MRIs (7T, 11.7T and 17.T), an MEG system, and a 3-photon imaging system. The MEG is a 306-channel system (Neuromag/Elekta) typically paired with EEG (native + EGI) and eye-tracking (Eyelink 1000 SR Research).

NeuroSpin teams develop advanced post-processing tools for structural image processing (BrainVisa), fMRI data analysis (Nipy, Nilearn), diffusion imaging (Connectomist), and M/EEG analysis (MNE Python). A 150-terabyte data archiving system, a large local computer cluster and access to the new CEA supercomputer are available. Neurospin’s environment also benefits from the new NeuroPSI building, dedicated to fundamental neuroscience and opening very soon.

[1] E. Labyt et al., IEEE Transactions on Medical Imaging (2019).

[2] W. Fourcault et al., Helium-4 magnetometers for room-temperature biomedical imaging: toward collective operation and photon-noise limited sensitivity (2021)

[3] D. Trübutschek et al , PNAS Probing the limits of activity-silent non-conscious working memory (2019).


Postdoctoral Opportunities – EXPERIENCE

CEA NeuroSpin – INSERM Cognitive Neuroimaging Unit

Cognition & Brain Dynamics Lab

Keywords: M/EEG, virtual reality, temporal cognition, multisensory perception, AI, machine learning

 

Applications are invited for a full-time post-doctoral cognitive neuroscientist in the European consortium “Extended-personal reality: augmented recording and transmission of virtual senses through artificial-intelligence” (see abstract p.2). EXPERIENCE involves eight academic and industrial partners with complementary expertise in artificial intelligence, neuroscience, psychiatry, neuroimaging, MEG/EEG/physiological recording techniques, and virtual-reality. The postdoctoral position will be fully dedicated to the Scientific foundation for the Extended-Personal Reality, a work package lead by the CEA (Virginie van Wassenhove) in collaboration with Univ. of Pisa (Gaetano Valenza, Mateo Bianchi), Padova (Claudio Gentilli), Roma Tor Vergata (Nicola Toschi) and others…

The candidates will have significant experience using time-resolved neuroimaging techniques (EEG, MEG), a solid research record in cognitive neurosciences, psychology and/or related fields, and some knowledgeable interest in exploring (spatio)temporal cognition in virtual reality. The selected postdoctoral fellow will be located at Neurospin and work collaboratively with the experts of the consortium. The postdoctoral fellow will be responsible for the development and transfer of knowledge, will contribute to the validation of novel experimental protocols, their implementation with combined virtual reality and neuroimaging, and state-of-the art analyses approaches. He/she will benefit from the interdisciplinary collaboration, and will be scientifically central to the advancement of the project. He/she will be involved in the organizational and managerial aspects of the project, including the supervision of students, the organization of meetings and project reports.

 

Requirements for the candidates:

–          hold a PhD in cognitive neurosciences, neurosciences, psychology, and/or related fields;

–          solid record of internationally peer-reviewed scientific work;

–          expertise or strong interest in time perception, multisensory perception, temporal and/or spatial cognition;

–          solid understanding of statistics or machine learning skills;

–          prior experience with EEG or MEG methods ;

–          signal processing and programming skills (matlab; python a plus);

–          autonomy and capacity to lead one’s project independently as well as collaborate with others

–          be an overall good lab citizen;

–          fluid mastery of both oral and written English

 

Expected Starting date: late 2021 or 2022]

 

Salary: commensurate with experience; positions will be funded for up to 3 years.

 

Application package

·       CV (incl. a list of publications)

·       A reprint of what you consider to be your best work

·       A letter of intent with a statement of research interests

·       Two letters of recommendation (or contacts from which those could be obtained)

 

Please specify “Experience Project 2” in the email subject line and send your application package to Virginie.van.Wassenhove@gmail.com

European Commission Horizon 2020 – Research and Innovation Framework Programme

 

 

[EXPERIENCE]

Extended-Personal Reality: augmented recording and transmission of virtual senses through artificial-intelligence

 

Social media has transformed the way we communicate through text, images, and videos. Despite recent technological avenues, virtual reality (VR) has not been incorporated in social platforms, hence limiting the comprehensive sharing of an experience. This project makes real the complex interplay between multisensory perception, emotional responses, past experiences, and perspective of the future also by disentangling the mental representation of self in space and time. The new Extended-Personal Reality technological and scientific paradigms will move Europe to the future generation of extended social interactions by allowing the public at large to i) create their own VR environments as they do photos and videos without the need for technical skills, ii) create virtual simulations eliciting unique psychological, cognitive, neurophysiological, and behavioural responses, iii) automatically generate VR environments from neurophysiological data, iv) easily manipulate VR environments to communicate and elicit specific emotions, v) manipulate perceived reality to effectively treat psychiatric disorders. EXPERIENCE embeds advanced artificial intelligence routines merging information from a person’s Extended-Personal Reality to inform manipulation tools including neuromodulation, multisensory biofeedback (audio, video, haptics), and subjective perception of time-space. EXPERIENCE will produce extremely realistic reproductions of the user’s past and may re-administer it by modulating the associated emotional states on demand. Within a large number of research and innovation avenues, EXPERIENCE will prioritise novel diagnosis and treatment of affective disorders commonly associated with altered multisensory perception like depression, anxiety, and eating disorders. A plethora of innovative technological paradigms including gaming, e-learning, and neuroeconomics will be in the commercial exploitations, including the opening of a new market for actually selling EXPERIENCEs.

 

Partners:

– Università di Pisa (UNIPI) (COORDINATOR)

– Centre Suisse d´Electronique et de microtechnique (CSEM)

– Università di Roma “Tor Vergata” (UNITOV)

– Comissariat à l´Energie Atomique et Aux Energies Alternatives (CEA) – France

– University of Padua (UNIPD)

– Karolinkska Institutet (KI)

– Quatechnion (QU)

 

 

Within the EXPERIENCE consortium, the goal of the scientific foundation for extended-personal reality work package is to investigate the functional correlates of known and novel temporal illusions in perception and cognition. The interferences between time and space, both at low-levels (e.g. kappa effect, temporal dilation; Project 1) and higher levels (e.g. mental distances; Project 2) are of particular interest in this project.

Both projects will use human psychophysics, VR, physiological recordings (EKG, GSR) and time-resolved neuroimaging techniques (MEG, EEG). State-of-the-art statistical techniques will be used to assess oscillatory coupling in brain activity as well as decoding and machine learning techniques.

 

•  Post-Doctoral Project  •

Spatiotemporal Interferences in Prospective and Retrospective Experiences of Time

The human spatial navigation system (the so-called ‘GPS’ of the brain) encompasses hippocampal brain structures and provides a flexible internal mapping of a subject’s spatial position with respect to its environmental landmarks. These structures are involved in spatial navigation and episodic memory. However, very little is known regarding how time is perceived during navigation and episodic encoding: are temporal experiences (e.g. order, duration, speed) compressed in memory like any other informational content? Is time lost and reconstructed a posteriori? Does this reconstruction also support our experience of time in real-time? We will bring temporal distortions to VR, explore spatio-temporal interferences and see how they affect mental mapping.